KLF15 and metformin action Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action Running title: KLF15 and metformin action
نویسندگان
چکیده
1 Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. 2 Frontier Science Organization, Kanazawa University, Kanazawa 920-8641, Japan. 3 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, 7708503, Japan. 4 Pharmacology Research Laboratories, Dainippon Sumitomo Pharmaceuticals Co. Ltd., Osaka 554-0022, Japan. 5 Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan.
منابع مشابه
Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
OBJECTIVE An increase in the rate of gluconeogenesis is largely responsible for the hyperglycemia in individuals with type 2 diabetes, with the antidiabetes action of metformin being thought to be achieved at least in part through suppression of gluconeogenesis. RESEARCH DESIGN AND METHODS We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis a...
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